Necrosulfonamide
A small molecule covalent inhibitor of mixed lineage kinase domain like protein (MLKL) that specifically blocks necrosis downstream of RIP3 activation; binds within the N-terminal 178 residues of human MLKL; arrests necrosis at a specific step at which RIP3 formed discrete punctae in cells. (In Vitro) :Necrosulfonamide specifically blocks necrosis downstream of RIP3 activation. Necrosulfonamide inhibits MLKL-mediated necrosis by blocking Its N-terminal CC domain function.
Product Specifications
CAS Number
1360614-48-7
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 28 mg/mL
Smiles
COC1=NC=CN=C1NS (=O) (=O) C2=CC=C (C=C2) NC (=O) /C=C/C3=CC=C (S3) [N+] (=O) [O-]
Molecular Formula
C18H15N5O6S2
Molecular Weight
461.4716
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2-Propenamide, N-[4-[[ (3-methoxy-2-pyrazinyl) amino]sulfonyl]phenyl]-3- (5-nitro-2-thienyl) -, (2E) -
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