Salicylic acid

Salicylic acid (2-Hydroxybenzoic acid) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation[1].

Product Specifications

CAS Number

[69-72-7]

Product Name Alternative

2-Hydroxybenzoic acid

UNSPSC

12352005

Hazard Statement

H302, H318, H361

Target

Apoptosis; Autophagy; COX; Endogenous Metabolite; Mitophagy

Type

Natural Products

Related Pathways

Apoptosis; Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/Salicylic-acid.html

Purity

99.83

Solubility

DMSO : ≥ 50 mg/mL|H2O : 1 mg/mL (ultrasonic)

Smiles

O=C(O)C1=CC=CC=C1O

Molecular Formula

C7H6O3

Molecular Weight

138.12

Precautions

H302, H318, H361

References & Citations

[1]Mitchell JA, et al. Sodium salicylate inhibits cyclo-oxygenase-2 activity independently of transcription factor (nuclear factor kappaB) activation: role of arachidonic acid. Mol Pharmacol. 1997 Jun;51 (6) :907-12.|[2]Nixon M, et al. Salicylate downregulates 11β-HSD1 expression in adipose tissue in obese mice and in humans, mediating insulin sensitization. Diabetes. 2012 Apr;61 (4) :790-6.