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Poziotinib

Poziotinib (HM781-36B, NOV120101) is an irreversible pan-HER inhibitor with IC50 of 3.2/5.3 nM/23.5 nM for HER1/HER2/HER4; inhibits phosphorylation of HER family and downstream signaling molecules, and induced apoptosis and G1 arrest; exerts synergistic effects with chemotherapeutic agents.Breast Cancer Phase 2 Clinical.

Product Specifications

CAS Number

1092364-38-9

Product Name Alternative

HM781-36B | NOV120101

Purity

>98% (HPLC)

Solubility

10 mM in DMSO

Smiles

C=CC (N1CCC (OC2=CC3=C (NC4=CC=C (Cl) C (Cl) =C4F) N=CN=C3C=C2OC) CC1) =O

Molecular Formula

C23H21Cl2FN4O3

Molecular Weight

491.3423

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

2-Propen-1-one, 1-[4-[[4-[ (3,4-dichloro-2-fluorophenyl) amino]-7-methoxy-6-quinazolinyl]oxy]-1-piperidinyl]-

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