NVP-BSK805
A potent, selective and ATP-competitive inhibitor of JAK2 (V617F) and wt JAK2 (IC50=0.5 nM) ; displays >20-fold selectivity towards JAK1, JAK3, TYK2 and excellent selectivity in broader kinase profiling; blunts constitutive STAT5 phosphorylation in JAK2 (V617F) -bearing cells; exhibits good oral bioavailability and a long half-life.
Product Specifications
CAS Number
1092499-93-8
Product Name Alternative
BSK 805 | BSK-805 | BSK805 | NVP-BSK 805
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
FC1=C (CN2CCOCC2) C (F) =CC (C3=C4N=C (C5=CN (C6CCNCC6) N=C5) C=NC4=CC=C3) =C1
Molecular Formula
C27H28F2N6O
Molecular Weight
490.5476
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Quinoxaline, 8-[3,5-difluoro-4- (4-morpholinylmethyl) phenyl]-2-[1- (4-piperidinyl) -1H-pyrazol-4-yl]-
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