BIX02189 (b)
BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM, also inhibits ERK5 catalytic activity with IC50 of 59 nM in cell-free assays, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2.
Product Specifications
CAS Number
1094614-85-3
Purity
>98% (HPLC)
Solubility
Ethanol: 80 mg/mL (181.59 mM) ; DMSO: 60 mg/mL warmed (136.19 mM)
Smiles
CN (C) CC1=CC (=CC=C1) N/C (=C\2/C3=C (C=C (C=C3) C (=O) N (C) C) NC2=O) /C4=CC=CC=C4
Molecular Formula
C27H28N4O2
Molecular Weight
440.54
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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