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CCT 137690

A potent, orally bioavailable Aurora kinases inhibitor with IC50 of 15/25/19 nM for Aurora A/B/C; displays antiproliferative activity in a range of human tumor cell lines, including SW620 colon carcinoma (GI50=0.30 uM) and A2780 ovarian cancer cell line (GI50=0.14 uM) ; exhibits in vivo efficacy with no observed toxicities in SW620 colon carcinoma xenografts.

Product Specifications

CAS Number

1095382-05-0

Product Name Alternative

CCT-137690 | CCT137690

Purity

>98% (HPLC)

Solubility

10 mM in DMSO

Smiles

CN1CCN (C2=CC=C (C3=NC4=C (N5CCN (CC6=NOC (C) =C6) CC5) C (Br) =CN=C4N3) C=C2) CC1

Molecular Formula

C26H31BrN8O

Molecular Weight

551.4813

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

3H-Imidazo[4,5-b]pyridine, 6-bromo-7-[4-[ (5-methyl-3-isoxazolyl) methyl]-1-piperazinyl]-2-[4- (4-methyl-1-piperazinyl) phenyl]-

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