ITD-1
ITD-1 is a potent, selective TGF-β inhibitor that induces type II TGFβ receptor (TGFBR2) degradation with IC50 of 0.85 uM, enhances proteasomal degradation of TGFBR2; effectively clears the receptor from the cell surface and selectively inhibits intracellular signaling; selectively enhances the differentiation of uncommitted mesoderm to cardiomyocytes, but not to vascular smooth muscle and endothelial cells.
Product Specifications
CAS Number
1099644-42-4
Product Name Alternative
ITD-1
Purity
>98% (HPLC)
Solubility
DMSO: < 9 mg/mL
Smiles
O=C (C1=C (C) NC2=C (C (CC (C) (C) C2) =O) C1C3=CC=C (C4=CC=CC=C4) C=C3) OCC
Molecular Formula
C27H29NO3
Molecular Weight
415.524
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
3-Quinolinecarboxylic acid, 4-[1,1'-biphenyl]-4-yl-1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-5-oxo-, ethyl ester
Available Sizes
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