Salermide
A potent Sirtuin inhibitor with IC50 of 76 and 45 uM for SIRT1 and SIRT2, respectively; prompts tumour-specific cell death in a wide range of human cancer cell lines (MCF cells at 50 uM), causes cell cycle arrest at G (1), results in the in vivo acetylation of the SIRT1/2 target p53, but not EX527.
Product Specifications
CAS Number
1105698-15-4
Product Name Alternative
Salermide
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=C (NC1=CC=CC (/N=C/C2=C3C=CC=CC3=CC=C2O) =C1) C (C) C4=CC=CC=C4
Molecular Formula
C26H22N2O2
Molecular Weight
394.46508
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzeneacetamide, N-[3-[[ (2-hydroxy-1-naphthalenyl) methylene]amino]phenyl]-α-methyl-
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