Metformin hydrochloride

Metformin Hcl, a widely used anti-diabetic drug has potential efficacy as an anti-Y drug. Metformin inhibits the proliferation of a range of Y cells including prostate, colon, breast, ovarian, and glioma lines. (In Vitro) :Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) inhibits proliferation of ESCs in a concentration-dependent manner. The IC50 is 2.45 mM for A-ESCs and 7.87 mM for N-ESCs. Metformin shows pronounced effects on activation of AMPK signaling in A-ESCs from secretory phase than in cells from proliferative phase.Metformin hydrochloride (0-500 μM) decreases glycogen synthesis in a dose-dependent manner with an IC50 value of 196.5 μM in cultured rat hepatocytes.Metformin hydrochloride shows cell viability and cytotoxic effects on PC-3 cells with IC50 of 5 mM. (In Vivo) :Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride; 100 mg/kg, p.o.) alone, and metformin (25, 50, 100 mg/kg) with NSC 37745 groups attenuates myocyte necrosis through histopathological analysis.