Quetiapine Fumarate
Quetiapine Fumarate is an atypical antipsychotic used in the treatment of schizophrenia, bipolar I mania, bipolar II depression, bipolar I depression. (In Vitro) :Quetiapine (<100 μM; 24 hours) has no significant effect on cell viabilities.Quetiapine (10 μM) inhibits NO release, which increased by LPS (0.1-100 ng/mL) in concentration-dependent manner.Quetiapine (10 μM) also inhibits TNF-α synthesis. (In Vivo) :Quetiapine (10 mg/kg/day; ingested) can alleviate the recruitment and activation of microglia and promote myelin repair in Cuprizone (CPZ) -induced chronic mouse model of demyelination.
Product Specifications
CAS Number
111974-72-2
Product Name Alternative
ICI 204636
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO: 36 mg/mL (40.76 mM)
Smiles
C1CN (CCN1CCOCCO) C2=NC3=CC=CC=C3SC4=CC=CC=C42.C1CN (CCN1CCOCCO) C2=NC3=CC=CC=C3SC4=CC=CC=C42.C (=C/C (=O) O) \C (=O) O
Molecular Formula
C46H54N6O8S2
Molecular Weight
883.09
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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