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Amcasertib

A small-molecule inhibitor that inhibits Nanog and other CSC (cancer stem cells) pathways by targeting kinases; targets and inhibits one or more pathways involved in cancer stem cell survival, shows potential antineoplastic activity.Liver Cancer Phase 2 Clinical (In Vitro) :Amcasertib (0-1μM; 48h) inhibits the NANOG and CD133 expression in PC-9/GR cells. Amcasertib also significantly suppresses the growth of PC-9/GR cells in a dose-dependent manner.

Product Specifications

CAS Number

1129403-56-0

Product Name Alternative

BBI-503

Purity

>98% (HPLC)

Solubility

DMSO: ≥ 30 mg/mL

Smiles

O=C (C1=C (C) NC (/C=C2C (NC3=C/2C=C (C4=CSC (C5=CC=CC=C5) =N4) C=C3) =O) =C1C) NCCN (CC) CC

Molecular Formula

C31H33N5O2S

Molecular Weight

539.691

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

1H-Pyrrole-3-carboxamide, N-[2- (diethylamino) ethyl]-5-[[1,2-dihydro-2-oxo-5- (2-phenyl-4-thiazolyl) -3H-indol-3-ylidene]methyl]-2,4-dimethyl-

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