VER-155008
A potent Hsp70 family (Hsc70/Hsp7/Grp78) inhibitor with Kd of 80 nM for Grp78; shows cellular activity in HCT116 cells (GI50= 5uM), has similar potencies in both Grp78 and Hsp70; inhibits the proliferation of human breast and colon cancer cell lines with GI50s of 5.3-14.4 uM, and induces Hsp90 client protein degradation in both HCT116 and BT474 cells; induced caspase-3/7 dependent apoptosis in BT474 cells.
Product Specifications
CAS Number
1134156-31-2
Product Name Alternative
VER-155008 | VER 155008 | VER155008
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 37 mg/mL
Smiles
O[C@@H] ([C@H] ([C@H] (N1C (NCC2=CC=C (Cl) C (Cl) =C2) =NC3=C (N=CN=C31) N) O4) O) [C@H]4COCC5=CC=C (C#N) C=C5
Molecular Formula
C25H23Cl2N7O4
Molecular Weight
556.4006
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Adenosine, 5'-O-[ (4-cyanophenyl) methyl]-8-[[ (3,4-dichlorophenyl) methyl]amino]-
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