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E-4031 dihydrochloride

E-4031 is a class III antiarrhythmic agent that binds to Kv11.1 (hERG) and blocks the rapid delayed-rectifier K+ current (IKr), reversibly prolongs action potential duration in guinea pig papillary muscle and isolated ventricular myocytes, without affecting Na+ or Ca2+ inward currents.Heart Arrhythmia Phase 2 Clinical.

Product Specifications

CAS Number

113559-13-0

Product Name Alternative

E4031

Purity

>98% (HPLC)

Solubility

H2O : ≥ 50 mg/mL105.39 mM

Smiles

CC1=NC (=CC=C1) CCN2CCC (CC2) C (=O) C3=CC=C (C=C3) NS (=O) (=O) C.Cl.Cl

Molecular Formula

C21H29Cl2N3O3S

Molecular Weight

474.441

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

1-[2- (6-methyl-2pyridyl) ethyl]-4- (4-methylsulfonyl aminobenzoyl) piperidine dihydrochloride

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