E-4031 dihydrochloride
E-4031 is a class III antiarrhythmic agent that binds to Kv11.1 (hERG) and blocks the rapid delayed-rectifier K+ current (IKr), reversibly prolongs action potential duration in guinea pig papillary muscle and isolated ventricular myocytes, without affecting Na+ or Ca2+ inward currents.Heart Arrhythmia Phase 2 Clinical.
Product Specifications
CAS Number
113559-13-0
Product Name Alternative
E4031
Purity
>98% (HPLC)
Solubility
H2O : ≥ 50 mg/mL105.39 mM
Smiles
CC1=NC (=CC=C1) CCN2CCC (CC2) C (=O) C3=CC=C (C=C3) NS (=O) (=O) C.Cl.Cl
Molecular Formula
C21H29Cl2N3O3S
Molecular Weight
474.441
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1-[2- (6-methyl-2pyridyl) ethyl]-4- (4-methylsulfonyl aminobenzoyl) piperidine dihydrochloride
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