CX-5461
CX-5461 is the first potent, selective, orally bioavailable inhibitor of RNA polymerase I, selectively inhibits rRNA synthesis in HCT-116 cells with IC50 of 142 nM, 200-fold selectivity over Pol II; inhibits the initiation stage of rRNA synthesis and induces both senescence and autophagy, but not apoptosis, through a p53-independent process in solid tumor cell lines; demonstrates in vivo antitumor activity against human solid tumors in murine xenograft models.Solid Tumors Phase 2 Clinical.
Product Specifications
CAS Number
1138549-36-6
Product Name Alternative
CX 5461 | CX5461
Purity
>98% (HPLC)
Solubility
DMSO: < 5.3 mg/mL
Smiles
O=C (C1=C (SC2=CC=CC=C23) N3C4=C (C=CC (N5CCN (C) CCC5) =N4) C1=O) NCC6=NC=C (C) N=C6
Molecular Formula
C27H27N7O2S
Molecular Weight
513.61
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
5H-Benzothiazolo[3,2-a][1,8]naphthyridine-6-carboxamide, 2- (hexahydro-4-methyl-1H-1,4-diazepin-1-yl) -N-[ (5-methyl-2-pyrazinyl) methyl]-5-oxo-
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