PNU-74654
A novel potent Wnt/beta-catenin inhibitor by disrupting Tcf/β-catenin interaction; binds to β-catenin with Kd of 450 nM, significantly decreases NCI-H295 cell proliferation (96 h, IC50=69 nM), increases early and late apoptosis, decreases nuclear beta-catenin accumulation, impaires CTNNB1/beta-catenin expression and increases beta-catenin target genes.
Product Specifications
CAS Number
113906-27-7
Product Name Alternative
PNU74654 | PNU 74654
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 30 mg/mL
Smiles
O=C (N/N=C/C1=CC=C (C) O1) C2=CC=CC=C2OC3=CC=CC=C3
Molecular Formula
C19H16N2O3
Molecular Weight
320.34194
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzoic acid, 2-phenoxy-, 2-[ (5-methyl-2-furanyl) methylene]hydrazide
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
K6066602 1.0 µg DNA
Chsy1 sgRNA CRISPR Lentivector (Rat) (Target 1)
Sign In for Pricing
View Details ![Mouse Monoclonal DPH2 Antibody (OTI4E7) [Alexa Fluor 350]](https://cdn.genprice.uk/genprice/uk/genprice2.webp)
NBP2-70585AF350 0.1 mL
Mouse Monoclonal DPH2 Antibody (OTI4E7) [Alexa Fluor 350]
Sign In for Pricing
View Details 
sc-335366 500 mg
2,3-Dimethoxy-8-oxo-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline-13-carboxylic acid
Sign In for Pricing
View Details K6459505 3x 1.0 µg
Polr3g sgRNA CRISPR/Cas9 All-in-One Lentivector set (Rat)
Sign In for Pricing
View Details