PNU-74654
A novel potent Wnt/beta-catenin inhibitor by disrupting Tcf/β-catenin interaction; binds to β-catenin with Kd of 450 nM, significantly decreases NCI-H295 cell proliferation (96 h, IC50=69 nM), increases early and late apoptosis, decreases nuclear beta-catenin accumulation, impaires CTNNB1/beta-catenin expression and increases beta-catenin target genes.
Product Specifications
CAS Number
113906-27-7
Product Name Alternative
PNU74654 | PNU 74654
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 30 mg/mL
Smiles
O=C (N/N=C/C1=CC=C (C) O1) C2=CC=CC=C2OC3=CC=CC=C3
Molecular Formula
C19H16N2O3
Molecular Weight
320.34194
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzoic acid, 2-phenoxy-, 2-[ (5-methyl-2-furanyl) methylene]hydrazide
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