PF-8380
Potent autotaxin inhibitor (IC50 = 2.8 nM in isolated enzyme assay; 101 nM in human whole blood) . Modulates lysophosphatidic acid (LPA) levels in vivo and in vitro by directly inhibiting autotaxin; reduces LPA levels both in plasma and at site of inflammation. Orally available.
Product Specifications
CAS Number
1144035-53-9
Product Name Alternative
PF8380 | PF-8380 | PF 8380
Purity
>98% (HPLC)
Solubility
DMSO: 95 mg/mL (198.6 mM)
Smiles
O=C (N1CCN (CCC (C2=CC=C3NC (OC3=C2) =O) =O) CC1) OCC4=CC (Cl) =CC (Cl) =C4
Molecular Formula
C22H21Cl2N3O5
Molecular Weight
478.33
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
3,5-dichlorobenzyl 4- (3-oxo-3- (2-oxo-2,3-dihydrobenzo[d]oxazol-6-yl) propyl) piperazine-1-carboxylate
Available Sizes
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