WYE-125132
A potent, specific, ATP-competitive and orally active mTOR inhibitor with IC50 of 0.19 nM; dispalys high selectivity (>5,000-fold) over PI3Ks, the PI3K-related kinases hSMG1 and ATR, and a panel of 230 protein kinases; inhibits mTORC1-dependent phosphorylation of S6K (T389) and mTORC2-dependent phosphorylation of AKT (S473), inhibits cancer cell proliferation, cell cycle progression, and induces apoptosis; shows potent single-agent antitumor activity against multiple cancer models.
Product Specifications
CAS Number
1144068-46-1
Product Name Alternative
WYE-132 | WYE125132
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 62 mg/mL
Smiles
O=C (NC) NC1=CC=C (C2=NC (N3CC (O4) CCC4C3) =C5C (N (C (CC6) CCC76OCCO7) N=C5) =N2) C=C1
Molecular Formula
C27H33N7O4
Molecular Weight
519.5954
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Urea, N-[4-[1- (1,4-dioxaspiro[4.5]dec-8-yl) -4- (8-oxa-3-azabicyclo[3.2.1]oct-3-yl) -1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-N'-methyl-
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