J147
J-147 is a broad spectrum neuroprotective phenyl hydrazide compound (EC50=60-115 nM) with significant neurotrophic properties related to the induction of brain-derived neurotrophic factor (BDNF) . (In Vitro) :J-147 promotes HT22 and primary cell survival in a dose-dependent manner (EC50 value range of 0.06-0.115 μM) . (In Vivo) :J-147 (diet is prepared by the addition of J-147 at 200ppm; 6 months) enhances memory and dendritic spine number in old mice.The half life (t1/2) of J-147 is calculated at 1.5 hrs in plasma and 2.5 hrs in brain (per oral (PO) administration at a single dose of 20 mg/kg) .
Product Specifications
CAS Number
1146963-51-0
Product Name Alternative
J147 | J 147 | J-147
Purity
>98% (HPLC)
Solubility
Soluble in DMSO
Smiles
O=C (N (C1=CC=C (C) C=C1C) /N=C/C2=CC=CC (OC) =C2) C (F) (F) F
Molecular Formula
C18H17F3N2O2
Molecular Weight
350.34
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2,2,2-Trifluoroacetic acid 1- (2,4-Dimethylphenyl) -2-[ (3-methoxyphenyl) methylene]hydrazide
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