CCT196969
CCT196969 is a potent, orally bioavailable pan-RAF inhibitor with IC50 of 100, 40 and 12 nM for B-Raf, B-Raf V600E and C-Raf, respectively; also potently inhibits SRC (IC50=26 nM) and LCK (IC50=14 nM), does not inhibit MEK1 or the MEK1 kinase COT; inhibits cell proliferation of BRAF-selective-inhibitor-resistant cells with mean GI50 of 0.4 uM, NRAS mutant melanoma cells (GI50=0.6 uM) ; induces caspase 3 and PARP cleavage, induces apoptosis, inhibits the growth of PLX4720-resistant A375 xenografts (A375/R) in mice, without causing any body weight loss.
Product Specifications
CAS Number
1163719-56-9
Product Name Alternative
CCT-196969 | CCT 196969
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 32 mg/mL
Smiles
FC1=CC (OC2=C3C (NC (C=N3) =O) =NC=C2) =CC=C1NC (NC4=CC (C (C) (C) C) =NN4C5=CC=CC=C5) =O
Molecular Formula
C27H24FN7O3
Molecular Weight
513.5229
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Urea, N-[4-[ (3,4-dihydro-3-oxopyrido[2,3-b]pyrazin-8-yl) oxy]-2-fluorophenyl]-N'-[3- (1,1-dimethylethyl) -1-phenyl-1H-pyrazol-5-yl]-
Available Sizes
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