A66
A66 (p110α inhibitor A66) is a potent, highly specific p110α inhibitor with IC50 of 32, 30 and 43 nM for wt p110α, p110α E545K and p110α H1047R, respectively; displays little to no activity against p110β/γ/δ (IC50>3,000 nM), as well as class-III PI3Ks, mTOR, DNA-PK, and PI4Kα/β; induces reduction in focus formation CEF by the highly transforming iSH2 mutants KS459delN, DKRMNS560del, and K379E, blocks PI3K signalling and tumour growth in certain cell types.
Product Specifications
CAS Number
1166227-08-2
Product Name Alternative
A 66 | A-66
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=C (N1[C@H] (C (N) =O) CCC1) NC2=NC (C) =C (C3=CSC (C (C) (C) C) =N3) S2
Molecular Formula
C17H23N5O2S2
Molecular Weight
393.52
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1,2-Pyrrolidinedicarboxamide, N1-[2- (1,1-dimethylethyl) -4'-methyl[4,5'-bithiazol]-2'-yl]-, (2S) -
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