PKI-402
A potent dual PI3K/mTOR inhibitor with IC50 of 1/7/16/14/1.7 nM for PI3Kα/β/γ/δ/mTOR respectively; shows excellent suppression of Akt T308 phosphorylation (IC50=5 nM), and excellent inhibition of cell proliferation in several human cancer cell lines; shows excellent in vivo efficacy in various human cancer xenografts, good physical properties and PK parameters.
Product Specifications
CAS Number
1173204-81-3
Product Name Alternative
PKI 402 | PKI402
Purity
>98% (HPLC)
Solubility
DMSO: < 1 mg/mL
Smiles
O=C (NC1=CC=C (C (N2CCN (C) CC2) =O) C=C1) NC3=CC=C (C4=NC (N5CCOCC5) =C (N=NN6CC) C6=N4) C=C3
Molecular Formula
C29H34N10O3
Molecular Weight
570.6454
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Urea, N-[4-[3-ethyl-7- (4-morpholinyl) -3H-1,2,3-triazolo[4,5-d]pyrimidin-5-yl]phenyl]-N'-[4-[ (4-methyl-1-piperazinyl) carbonyl]phenyl]-
Available Sizes
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