SF2523
A novel potent, dual inhibitor of PI3K and BRD4 with IC50 of 241, 34, 158 nM for BRD4 (BD1), PI3Kα and PI3Kγ, respectively; interacts robustly with the full-length BRD4 (Kd=140 nM) and BRD4 (BD1) (Kd=150 nM), binds more weakly BRD4 (BD2) (Kd = 710 nM) ; blocks MYC expression and activation, promotes MYC degradation, and markedly inhibits cancer cell growth and metastasis both in vitro and in vivo.
Product Specifications
CAS Number
1174428-47-7
Product Name Alternative
SF-2523 | SF 2523
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 30 mg/mL
Smiles
O=C1C=C (N2CCOCC2) OC3=C1SC=C3C4=CC=C (OCCO5) C5=C4
Molecular Formula
C19H17NO5S
Molecular Weight
371.40698
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
7H-Thieno[3,2-b]pyran-7-one, 3- (2,3-dihydro-1,4-benzodioxin-6-yl) -5- (4-morpholinyl) -
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