CLP290
CLP290 (CLP-290) is an orally acirtve small molecule K+-Cl- cotransporter isotype 2 (KCC2) activator, the carbamate prodrug of CLP257; In vivo co-treatment with morphine and oral CLP290 prevented membrane KCC2 downregulation in SDH neurons. Concurrently, co-treatment with CLP290 significantly mitigated MIH and acute administration of CLP257 in established MIH restored normal nociceptive behavior.
Product Specifications
CAS Number
1181083-81-7
Product Name Alternative
CLP-290
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 33.33 mg/mL (82.41 mM)
Smiles
O=C (N1CCCC1) OC2=CC (F) =CC=C2/C=C (SC (N3CCCCN3) =N4) /C4=O
Molecular Formula
C19H21FN4O3S
Molecular Weight
404.46
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
[5-Fluoro-2-[ (Z) - (2-hexahydropyridazin-1-yl-4-oxo-thiazol-5-ylidene) methyl]phenyl] pyrrolidine-1-carboxylate
Available Sizes
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