Lafutidine

Lafutidine, a newly developed histamine H (2) -receptor antagonist, inhibits gastric acid secretion. (In Vitro) :Lafutidine exhibits gastric mucosal protective action mediated by capsaicin-sensitive afferent neurons, in addition to a potent antisecretory effect.Lafutidine (0.1-10 μM) significantly augments the periarterial nerve stimulation (PNS, 1 Hz) induced-vasodilation in a concentration-dependent manner in rat perfused mesenteric vascular beds. (In Vivo) :Lafutidine (3-30 mg/kg; p.o.; twice daily; for 6 days) dose-dependently reduces the severity of dextran sulfate Na (DSS) -induced colitis and significantly mitigates changes in the colon length and myeloperoxidase (MPO) activity.