MK-8617
A potent, orally active pan-inhibitor of HIF prolyl hydroxylase (HIF-PHD) with IC50 of 1.0,1.0, and 14 nM for HIF-PHD1, 2, and 3, respectively; shows no significant inhibition on the cytochrome p450 enzymes; exhibits good oral bioavailability, causes increases in circulating reticulocytes in mice and has potential for treatment of anemia.
Product Specifications
CAS Number
1187990-87-9
Product Name Alternative
MK 8617 | MK8617
Purity
>98% (HPLC)
Solubility
DMSO: 16 mg/mL (36.1 mM) (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
COC1=CC=C (C=C1) C (C2=CC=C (C=C2) OC) NC (=O) C3=CN=C (NC3=O) C4=NN=CC=C4
Molecular Formula
C24H21N5O4
Molecular Weight
443.45
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N-[Bis (4-methoxyphenyl) methyl]-4-hydroxy-2- (pyridazin-3-yl) pyrimidine-5-carboxamide
Available Sizes
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