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IOWH-032

A novel and potent CFTR inhibitor (IC50=1.01 uM) in T84 and CHO-CFTR cell based assays for the treatment of cystic fibrosis; potentially serves as lead compound for development of new drugs for the treatment of cystic fibrosis. (In Vitro) :IOWH-032 (10 μM; 0-72 h) increases the ACE-2 expression in SARS-CoV-2 infected CFBE41o- WT cells.

Product Specifications

CAS Number

1191252-49-9

Product Name Alternative

IOWH-032 | IOWH032 | IOWH 032

Purity

>98% (HPLC)

Solubility

10 mM in DMSO

Smiles

O=C (C1=NC (C2=CC (Br) =C (O) C (Br) =C2) =NO1) NCC3=CC=C (OC4=CC=CC=C4) C=C3

Molecular Formula

C22H15Br2N3O4

Molecular Weight

545.1802

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

1,2,4-Oxadiazole-5-carboxamide, 3- (3,5-dibromo-4-hydroxyphenyl) -N-[ (4-phenoxyphenyl) methyl]-

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