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PHT-427

PHT-427 is a small-molecule Akt inhibitor that binds selectively to the PH domain of AKT with Ki of 2.4 uM, inhibits phospho-Ser473-AKT in Panc-1 cells with IC50 of 6.3 uM; decreases AKT activation and causes apoptosis at low micromolar concentrations in Panc-1 and MiaPaCa-2 pancreatic cancer cell lines; inhibits AKT and its downstream targets in cells, exhibits good antitumor activity in pancreatic cancer cell xenografts in immunocompromised mice.

Product Specifications

CAS Number

1191951-57-1

Product Name Alternative

PHT 427 | PHT427

Purity

>98% (HPLC)

Solubility

10 mM in DMSO

Smiles

O=S (C1=CC=C (CCCCCCCCCCCC) C=C1) (NC2=NN=CS2) =O

Molecular Formula

C20H31N3O2S2

Molecular Weight

409.609

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

Benzenesulfonamide, 4-dodecyl-N-1,3,4-thiadiazol-2-yl-

Available Sizes

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