PHT-427
PHT-427 is a small-molecule Akt inhibitor that binds selectively to the PH domain of AKT with Ki of 2.4 uM, inhibits phospho-Ser473-AKT in Panc-1 cells with IC50 of 6.3 uM; decreases AKT activation and causes apoptosis at low micromolar concentrations in Panc-1 and MiaPaCa-2 pancreatic cancer cell lines; inhibits AKT and its downstream targets in cells, exhibits good antitumor activity in pancreatic cancer cell xenografts in immunocompromised mice.
Product Specifications
CAS Number
1191951-57-1
Product Name Alternative
PHT 427 | PHT427
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=S (C1=CC=C (CCCCCCCCCCCC) C=C1) (NC2=NN=CS2) =O
Molecular Formula
C20H31N3O2S2
Molecular Weight
409.609
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzenesulfonamide, 4-dodecyl-N-1,3,4-thiadiazol-2-yl-
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