JNJ-42041935
JNJ-42041935 is a potent, selective, 2-OG-competitive, reversible inhibitor of HIF-PHD with pKi of 7.91, 7.29 and 7.65 for PHD1, PHD2 and PHD3, respectively; shows highly selectivity for PHD relative to FIH (pIC50=4.0) ; JNJ-42041935 is approximately equipotent in the HIF-1α accumulation and erythropoietin secretion assays in Hep3B cells as DMOG and 3,4-EDHB; reverses inflammation-induced anemia at dose of 100 μmol/kg, whereas erythropoietin has no effect.
Product Specifications
CAS Number
1193383-09-3
Product Name Alternative
JNJ42041935
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 36 mg/mL
Smiles
ClC1=CC2=C (NC (N3C=C (C (O) =O) C=N3) =N2) C=C1OC (F) (F) F
Molecular Formula
C12H6ClF3N4O3
Molecular Weight
346.6493
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1H-Pyrazole-4-carboxylic acid, 1-[6-chloro-5- (trifluoromethoxy) -1H-benzimidazol-2-yl]-
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