Eliprodil
Eliprodil (SL-820715) is a non-competitive NR2B-NMDA receptor antagonist, less potent for NR2A- and NR2C-containing receptors (IC50>100 uM) ; inhibits [3H]norepinephrine release from cortical and hippocampal slices but enhances the basal efflux of endogenous and tritiated dopamine from striatal slices, also blocks the uptake of [3H]dopamine into striatal synaptosomes with IC50 of 1.5 uM; reduces the volume of infarction in models of focal cerebral ischemia.Stroke Phase 3 Discontinued.
Product Specifications
CAS Number
119431-25-3
Product Name Alternative
SL-820715
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
OC (C1=CC=C (Cl) C=C1) CN2CCC (CC3=CC=C (F) C=C3) CC2
Molecular Formula
C20H23ClFNO
Molecular Weight
347.8541
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1-Piperidineethanol, α- (4-chlorophenyl) -4-[ (4-fluorophenyl) methyl]-
Available Sizes
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