CPI-455
A potent, specific histone demethylase pan-KDM5 inhibitor with biochemical IC50 of 10, 3 and 14 nM for KDM5A, KDM5B and KDM5C, respectively; shows substantially weaker potency toward KDM4C and KDM7B (200- and 770-fold, respectively) and no inhibition of KDM2B, KDM3B or KDM6A; dose-dependently increases in H3K4 methylation in multiple cell lines, decreases the number of drug-tolerant persister cancer cells (DTPs) in multiple cancer cell line models treated with standard chemotherapy or targeted agents.
Product Specifications
CAS Number
1628208-23-0
Product Name Alternative
CPI455 | CPI 455
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 34 mg/mL
Smiles
N#CC1=C (NC (C2=CC=CC=C2) =C (C (C) C) C3=O) N3N=C1
Molecular Formula
C16H14N4O
Molecular Weight
278.3086
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Pyrazolo[1,5-a]pyrimidine-3-carbonitrile, 4,7-dihydro-6- (1-methylethyl) -7-oxo-5-phenyl-
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