RAF-709
A novel potent, selective, and orally bioavailable RAF inhibitor with biochemical IC50 of 0.4 nM and 0.5 nM for BRAF and CRAF, respectively; suppresses pERK (EC50=0.02-0.1 uM), stabilizes BRAF CRAF dimers (EC50=0.8 uM) inhibits proliferation (EC50=0.95 uM) in KRAS mutant tumor cell lines (Calu6) ; shows effectivity in a KRAS mutant xenograft model.
Product Specifications
CAS Number
1628838-42-5
Product Name Alternative
RAF709 | RAF 709
Field of Research
Neuroscience
Purity
>98% (HPLC)
Solubility
DMSO: 100 mg/mL
Smiles
CC1=C (C=C (C=N1) NC (=O) C2=CC (=CC=C2) C (F) (F) F) C3=CC (=C (N=C3) OC4CCOCC4) N5CCOCC5
Molecular Formula
C28H29F3N4O4
Molecular Weight
542.5495
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzamide, N-[2-methyl-5'- (4-morpholinyl) -6'-[ (tetrahydro-2H-pyran-4-yl) oxy][3,3'-bipyridin]-5-yl]-3- (trifluoromethyl) -
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