ARS-853
ARS-853 is a mutant-specific, covalent inhibitor of KRAS (G12C) ; engages KRASG12C in biochemical assay with a rate constant of 76 M-1s-1, > 600-fold improvement compared with Compound 12 (Ostrem JM, Nature 2013;503:548–51.) ; inhibits growth of H358 cells; the first direct KRAS inhibitor shown to selectively inhibit KRAS in cells with potency in the range of a drug candidate.
Product Specifications
CAS Number
1629268-00-3
Product Name Alternative
ARS853 | ARS 853
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 71 mg/mL
Smiles
C=CC (N1CC (N2CCN (C (CNC3=CC (C4 (C) CC4) =C (Cl) C=C3O) =O) CC2) C1) =O
Molecular Formula
C22H29ClN4O3
Molecular Weight
432.9437
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2-Propen-1-one, 1-[3-[4-[2-[[4-chloro-2-hydroxy-5- (1-methylcyclopropyl) phenyl]amino]acetyl]-1-piperazinyl]-1-azetidinyl]-
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