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LB-100

LB-100 (LB100) is a potent serine/threonine protein phosphatase 2A (PP2A) inhibitor; exhibits inhibitory effect in HCC cell lines Huh-7, HepG2, Hep3B, and SNU-449 with mean IC50 of 10 uM; synergistically enhances the activity of doxorubicin and induces expression of HIF-1α and VEGF; significantly enhances tumor growth inhibition by cisplatin in vivo.Brain Cancer Phase 1 Clinical.

Product Specifications

CAS Number

1632032-53-1

Product Name Alternative

LB100

Purity

>98% (HPLC)

Solubility

H2O: ≥ 48 mg/mL; DMSO: < 2.9 mg/mL

Smiles

O=C (C1C (O2) CCC2C1C (N3CCN (C) CC3) =O) O

Molecular Formula

C13H20N2O4

Molecular Weight

268.3089

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

7-Oxabicyclo[2.2.1]heptane-2-carboxylic acid, 3-[ (4-methyl-1-piperazinyl) carbonyl]-, (1R,4S) -rel-

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