LB-100
LB-100 (LB100) is a potent serine/threonine protein phosphatase 2A (PP2A) inhibitor; exhibits inhibitory effect in HCC cell lines Huh-7, HepG2, Hep3B, and SNU-449 with mean IC50 of 10 uM; synergistically enhances the activity of doxorubicin and induces expression of HIF-1α and VEGF; significantly enhances tumor growth inhibition by cisplatin in vivo.Brain Cancer Phase 1 Clinical.
Product Specifications
CAS Number
1632032-53-1
Product Name Alternative
LB100
Purity
>98% (HPLC)
Solubility
H2O: ≥ 48 mg/mL; DMSO: < 2.9 mg/mL
Smiles
O=C (C1C (O2) CCC2C1C (N3CCN (C) CC3) =O) O
Molecular Formula
C13H20N2O4
Molecular Weight
268.3089
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
7-Oxabicyclo[2.2.1]heptane-2-carboxylic acid, 3-[ (4-methyl-1-piperazinyl) carbonyl]-, (1R,4S) -rel-
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