YM-90709
A potent IL-5 receptor antagonist that inhibits the binding of IL-5 to its receptor on peripheral human eosinophils and butyric acid-treated eosinophilic HL-60 clone 15 cells with IC50 of 1.0 and 0.57 uM, respectively; inhibits IL-5-prolonged eosinophil survival with IC50 of 0.45 uM and does not affect the GM-CSF-prolonged eosinophil survival; inhibits antigen-induced infiltration of eosinophils and lymphocytes into the bronchoalveolar lavage fluid (BALF) in BN rats (EC50=0.32 mg/kg and 0.12 mg/kg, respectively) .
Product Specifications
CAS Number
163769-88-8
Product Name Alternative
YM 90709 | YM90709
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
CC (CC1=CC (OC) =C (OC) C=C12) (C) N3C2=CC4=NC5=CC=CC=C5N=C43
Molecular Formula
C22H21N3O2
Molecular Weight
359.4211
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benz[7,8]indolizino[2,3-b]quinoxaline, 5,6-dihydro-2,3-dimethoxy-6,6-dimethyl-
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