Autophinib
Autophinib is a novel, potent autophagy inhibitor that inhibits autophagy induced by starvation (IC50=90 nM) or rapamycin (IC50=40 nM) by targeting the lipid kinase VPS34 (IC50=19 nM) ; inhibits LC3 lipidation to form LC3-II, also inhibits p62 degradation dose-dependently in starved MCF7-LC3 cells; an ATP-competitive inhibitor of VPS34 but not other lipid kinases, mTOR and TBK1.
Product Specifications
CAS Number
1644443-47-9
Product Name Alternative
Autophinib
Purity
>98% (HPLC)
Solubility
DMSO: 64 mg/mL (184.6 mM) ; Ethanol: <1 mg/mL; Water: <1 mg/mL (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
O=[N+] (C1=CC=C (OC2=NC (Cl) =CC (NC3=NNC (C) =C3) =N2) C=C1) [O-]
Molecular Formula
C14H11ClN6O3
Molecular Weight
346.731
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
6-Chloro-N- (5-methyl-1H-pyrazol-3-yl) -2- (4-nitrophenoxy) pyrimidin-4-amine
Available Sizes
Frequently Asked Questions
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