GLPG-1837
GLPG-1837 (ABBV-974) is a potent, orally available CFTR potentiator with EC50 of 3 nM and 339 nM on F508del and G551D CFTR, respectively; shows enhanced efficacy on CFTR mutants harboring Class III mutations compared to Ivacaftor.Cystic Fibrosis, Phase 2 Clinical (In Vitro) :GLPG1837 is a potent CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively. GLPG1837 increases the conductivity of the G551D CFTR channel with obtained potency of 181 nM. GLPG1837 is reversible CFTR potentiator, with a the apparent affinity within a range of 0.2~2 μM.
Product Specifications
CAS Number
1654725-02-6
Product Name Alternative
GLPG1837 | GLPG 1837 | ABBV-974
Purity
>98% (HPLC)
Solubility
Ethanol: 5 mg/mL; Water: Insoluble; DMSO: 60 mg/mL (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
O=C (C1=NNC=C1) NC (S2) =C (C (N) =O) C3=C2C (C) (C) OC (C) (C) C3
Molecular Formula
C16H20N4O3S
Molecular Weight
348.421
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N- (3-carbamoyl-5,5,7,7-tetramethyl-4,7-dihydro-5H-thieno[2,3-c]pyran-2-yl) -1H-pyrazole-5-carboxamide
Available Sizes
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