Indisulam
Indisulam (E7070) is potent, sulfonamide, cell-cycle inhibitor that possesses antiproliferative activities, causes decrease in the S phase fraction along with G1 and/or G2 accumulation in various cancer cell lines; causes blockade in the G1/S transition through inhibition of the activation of both cyclin-dependent kinase 2 and cyclin E, shows activity in multiple tumor types, most prominently in colon and lung cancer.Breast Cancer Phase 2 Discontinued (In Vitro) :Indisulam (E7070, 0-50 μg/mL, 12-48 h) causes cell cycle perturbation in the G1 phase in a time- and dose-dependent manner, potentially leading to cell death. (In Vivo) :Indisulam (E7070, 12.5, 25, 50 (100) mg/kg) shows an antitumour spectrum in human cancer models.
Product Specifications
CAS Number
165668-41-7
Product Name Alternative
E 7070 | E7070
Purity
>98% (HPLC)
Solubility
DMSO: 20mg/mL (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
O=S (C1=CC=C (S (=O) (N) =O) C=C1) (NC2=CC=CC3=C2NC=C3Cl) =O
Molecular Formula
C14H12ClN3O4S2
Molecular Weight
385.85
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N- (3-chloro-7-indolyl) -1,4-benzenedisulfonamide
Available Sizes
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