Naltrexone hydrochloride
A potent, competitive antagonist for μ, κ, δ, and σ-opioid receptors with Ki of 0.0825 nM, 0.509 nM, and 8.02 nM, for MOR, KOR, and DOR, respectively; also inhibits IL-6 and TNFα production in human immune cell subsets following stimulation with ligands for intracellular TLRs; a TLR-4 antognist that inhibits LPS-induced TLR4 downstream NO production in microglia BV-2 cells (IC50=105 uM) .Alcoholism Approved.
Product Specifications
CAS Number
16676-29-2
Product Name Alternative
NIH 8503
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 33 mg/mL
Smiles
C1CC1CN2CC[C@]34[C@@H]5C (=O) CC[C@]3 ([C@H]2CC6=C4C (=C (C=C6) O) O5) O.Cl
Molecular Formula
C20H24ClNO4
Molecular Weight
377.8618
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Morphinan-6-one, 17- (cyclopropylmethyl) -4,5-epoxy-3,14-dihydroxy-, hydrochloride (1:1), (5α) -
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