Compound 401
A synthetic inhibitor of DNA-PK also inhibits mTOR (IC50=5.3 uM) ; no inhibition on p110α/p85α PI3K (>100 uM) ; blocks the phosphorylation of S6 kinase 1 Thr389 and Akt Ser473 in COS7 cells.
Product Specifications
CAS Number
168425-64-7
Product Name Alternative
Compound-401 | Compound401
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO: 6 mg/mL
Smiles
O=C1C=C (N2CCOCC2) N=C3N1C=CC4=C3C=CC=C4
Molecular Formula
C16H15N3O2
Molecular Weight
281.3092
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4H-Pyrimido[2,1-a]isoquinolin-4-one, 2- (4-morpholinyl) -
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