EPZ020411
EPZ020411 is a potent, selective PRMT6 inhibitor with IC50 of 10 nM, displays 10-fold and 20-fold selectivity over PRMT1/8, and >100-fold over other histone methyltransferases (PRMT3/4/5/7) ; dose-dependently decreases H3R2 methylation A375 cell line with IC50 of 0.637 uM, with no affect levels of PRMT6 expression; exhibits good bioavailability following subcutaneous dosing in rats making it a suitable tool for potential in vivo target validation studies.
Product Specifications
CAS Number
1700663-41-7
Product Name Alternative
EPZ-020411
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
CNCCN (C) CC1=C (NN=C1) C2=CC=C (C=C2) OC3CC (C3) OCCC4CCOCC4
Molecular Formula
C25H38N4O3
Molecular Weight
442.5942
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1,2-Ethanediamine, N1, N2-dimethyl-N1-[[3-[4-[[trans-3-[2- (tetrahydro-2H-pyran-4-yl) ethoxy]cyclobutyl]oxy]phenyl]-1H-pyrazol-4-yl]methyl]-
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