JH-II-127
A potent and selective inhibitor of both wild-type and G2019S mutant LRRK2 with IC50 of 6.6 and 2.2 nM, respectively; also inhibits LRRK2 A2016T with IC50 of 47.7 nM; substantially inhibits Ser910 and Ser935 phosphorylation of both wild-type LRRK2 and G2019S mutant at 0.1-0.3 uM in a variety of cell types; inhibits Ser935 phosphorylation in mouse brain; orally active.Parkinson's Disease Preclinical.
Product Specifications
CAS Number
1700693-08-8
Product Name Alternative
JH-II-127 | JH-II 127 | JH-II127
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 30 mg/mL
Smiles
ClC1=CNC2=C1C (NC) =NC (NC3=C (OC) C=C (C (N4CCOCC4) =O) C=C3) =N2
Molecular Formula
C19H21ClN6O3
Molecular Weight
416.8615
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Methanone, [4-[[5-chloro-4- (methylamino) -7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-4-morpholinyl-
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