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NQDI-1

NQDI-1 is a potent and selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with Ki of 500 nM; inhibits in vivo expression levels of ASK1, phosphorylated (p) JNK, p c Jun, p53 and caspase 3 in Hypoxia-ischemia rat model; enhances endochondral bone formation by increasing chondrocyte survival in mice.

Product Specifications

CAS Number

175026-96-7

Product Name Alternative

NQDI 1

Purity

>98% (HPLC)

Solubility

DMSO: 10 mg/mL

Smiles

O=C (C1=C2C3=C (NC1=O) C=CC=C3C (C4=C2C=CC=C4) =O) OCC

Molecular Formula

C19H13NO4

Molecular Weight

319.3108

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

3H-Naphtho[1,2,3-de]quinoline-1-carboxylic acid, 2,7-dihydro-2,7-dioxo-, ethyl ester

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