NCB-0846
The first orally available, small-molecule TNIK inhibitor with IC50 of 21 nM; also weakly inhibits FLT3, JAK3, PDGFRα, TRKA, CDK2/CycA2, and HGK (IC80>0.1 uM) ; induces faster migration of TCF4 phosphorylated by TNIK at 0.1-0.3 uM, and completely inhibits at 3 uM; also reduces the expression of TNIK, AXIN2, cMYC, LRP6 and LRP5; abrogates colorectal cancer stemness, suppresses Wnt-driven intestinal tumorigenesis in Apc (min/+) mice. Colon Cancer Preclinical.
Product Specifications
CAS Number
1792999-26-8
Product Name Alternative
NCB 0846 | NCB0846
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 30 mg/mL
Smiles
O[C@H]1CC[C@@H] (OC2=CC=CC3=CN=C (NC4=CC=C5N=CNC5=C4) N=C23) CC1
Molecular Formula
C21H21N5O2
Molecular Weight
375.4237
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Cyclohexanol, 4-[[2- (1H-benzimidazol-6-ylamino) -8-quinazolinyl]oxy]-, cis-
Available Sizes
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