DBET1
DBET1 is a proteolysis-targeting chimera (PROTAC) molecule that appendes a competitive antagonist of BET bromodomain (JQ1) to a phthalimide moiety to hijack the cereblon E3 ubiquitin ligase complex; induces highly selective cereblon-dependent BET protein degradation in vitro (EC50=430 nM) and in vivo and delayed leukemia progression in mice.
Product Specifications
CAS Number
1799711-21-9
Product Name Alternative
DBET 1
Purity
>98% (HPLC)
Solubility
DMSO: 50 mg/mL; Water: Insoluble; Ethanol: 5 mg/mL (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
CC (N (C1C2=NN=C (C) N2C3=C (C (C) =C (C) S3) C (C4=CC=C (Cl) C=C4) =N1) CCCCNC (COC5=CC=CC (C (N6C (CC7) C (NC7=O) =O) =O) =C5C6=O) =O) =O
Molecular Formula
C38H37ClN8O7S
Molecular Weight
785.273
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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