Imidazole ketone erastin
Imidazole ketone erastin (IKE, Ferroptosis inducer IKE) is a potent, metabolically stable inhibitor of system xc- and inducer of ferroptosis potentially suitable for in vivo applications; potently reduces DLBCL cell number with IC50 of <100 nM (SUDHL6 cell IC50=1 nM) ; exerts antitumor effect by inhibiting system xc-, leading to glutathione depletion (GSH depletion IC50=34 nM, SUDHL6 cells), lipid peroxidation, and the induction of ferroptosis biomarkers both in vitro and in vivo, induced lipid peroxidation in tumor tissue.
Product Specifications
CAS Number
1801530-11-9
Product Name Alternative
Ferroptosis inducer IKE | IKE
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 125 mg/mL 190.80 mM
Smiles
O=C1N (C2=CC (C (CN3C=NC=C3) =O) =CC=C2OC (C) C) C (CN4CCN (C (COC5=CC=C (Cl) C=C5) =O) CC4) =NC6=C1C=CC=C6
Molecular Formula
C35H35ClN6O5
Molecular Weight
655.152
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
3- (5- (2- (1H-imidazol-1-yl) acetyl) -2-isopropoxyphenyl) -2- ((4- (2- (4-chlorophenoxy) acetyl) piperazin-1-yl) methyl) quinazolin-4 (3H) -one
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