PF-06260933
PF-06260933 (PF06260933, PF6260933) is a potent, selective, orally available MAP4K4 inhibitor with IC50 of 3.7 nM; demonstrates very good selectivity against more than 150 native kinases, with only the closely related GCK family members (ZC2, TNIK and ZC3, MINK 70% inhibition at 1 uM) ; inhibits LPS-induced plasma TNFα levels in mouse model.
Product Specifications
CAS Number
1811510-56-1
Product Name Alternative
PF 6260933 | PF6260933
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
C1=CC (=CC=C1C2=C (N=CC (=C2) C3=CN=C (C=C3) N) N) Cl
Molecular Formula
C16H13ClN4
Molecular Weight
296.754
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
5- (4-chlorophenyl) -[3,3'-bipyridine]-6,6'-diamine
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